MeltPrep at AAPS PharmSci 360 2020 

Discover the fastest way from powder to sample.

The MeltPrep VCM Technology is the first lossless method for the screening of thermoplastic dosage forms (e.g. amorphous solid dispersions or implants in the milligram to gram-scale such as ASDs or implants). 

VCM Tool

Perfect samples

Powder

or extrudates, flakes etc.

Hot-melt

Extrusion-like 

The VCM Process holds the balance between input and output material. It’s the first lossless approach to melt samples into a defined shape, without air inclusions. With 1 gram of powder, you will obtain a cylindrical sample of 1 gram with a defined shape.

scale.jpg

Input

Output

Lossless process

We offer a broad range of VCM Tool Inserts starting from 25 mm (up to 5g) to 0.3 mm (down to 200 μg) to address your needs in material characterization and formulation development.  

Disc Tool

Bar Tool

Areas of application 

Explore your opportunities.

Intrinsic dissolution

MeltPrep samples can be used for intrinsic dissolution testing giving valuable insights into formulations characteristics. The samples have defined geometries and release the drug via a defined surface, thus specific drug release properties can be derived from testing.

Cup

Sample

Dissolution

vessel

DSC Measurements (Discs 5 mm)

Samples are placed in a crucible and subjected to a controlled heat transfer cycle. Particle boundaries hinder heat transfer. Homogeneous VCM samples ensure uniform heat transfer and will lead to more significant results.

Powder

VCM sample

1st

heating

1st

heating

DSC

crucible

Phase

Boundaries

Homogeneous

Diffusion Studies  (Discs 8-25 mm)

Multilayer samples are requested in galenics to study drug diffusion and release. They are also used for controlled release drugs. A well-known example is the intra-vaginal birth control ring (IVR) from Merck (NuvaRing™).

Drug loaded core

Diffusion barrier

100 pm

4 mm

Diffusion barrier

100 pm

Lateral surface

sealed with

barrier glue

e.g. Ø10 mm

Cross

section

IVR e.g. Ø 50 mm

Drug loaded core

Diffusion barrier

Watch the video

See how it works.

To have more insights about VCM Technology, watch the dedicated videos. Interested? Book a free video demo to see the real process happening!

Check our product portfolio

The best for your research.

VCM

VChamber

ExtruVis

Trivia Challenge Answers

Did you guess right?

Question 1. Answer: b)

Vacuum Compression Molding (VCM) Technology allows the lossless preparation of thermoplastic dosage forms (e.g. ASDs, implants, multilayered samples, in the milligram to gram-scale). It’s the first lossless approach to melt material into a defined shape without air inclusions, making it a powerful tool to speed up pharmaceutical formulation and process design. 

Question 2. Answer: a)

Having expensive equipment or a massive amount of testing material is not needed to obtain reproducibility. With MeltPrep VCM, you have the best reproducible characterization results, without losing material.