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VCM_HME ASD and implant formulation screening

VCM Publications

MeltPrep accelerates research.

Good sample quality is vital for reliable and reproducible material characterizations. Scientific users and quality managers get the most out of their characterization from flawless samples. VCM is a novel approach to screening polymers using a minimum quantity of active pharmaceutical ingredients. Read our latest publication to find out.

Pharmaceutical Applications

VCM Technology is designed for highly challenging pharmaceutical requirements. Our system's benefits have already attracted the attention of different industries. Read the peer-reviewed publications and explore the different pharmaceutical applications involving VCM Technology.

Title
Authors
Company/Institution
Year
Measuring and Modeling of Melt Viscosity for Drug Polymer Mixtures
Markus Thommes
TU Dortmund
2024
In Situ Imaging of Subcutaneous Drug Delivery Systems Using Microspatially Offset Low-Frequency Raman Spectroscopy
Ka̅rlis Be̅rziņš
University of Copenhagen
2024
Evaluation of Printability of PVA-Based Tablets from Powder and Assessment of Critical Rheological Parameters
Jonas Lenhart
Eberhard Karls University
2024
Concordance of vacuum compression molding with spray drying in screening of amorphous solid dispersions of itraconazole
James Polli
University of Maryland
2024
Exploring Vacuum Compression Molding as a Preparation Method for Flexible-Dose Pediatric Orodispersible Film
Dana Hales
Iuliu Hatieganu University of Medicine and Pharmacy
2024
Toward high-resolution 3D-printing of pharmaceutical implants – A holistic analysis of relevant material properties and process parameters
Martin Spoerk
Research Center Pharmaceutical Engineering GmbH
2024
3D Printing of prolonged-release oral solid dosage forms containing Felodipine
R. Iuliu Iovanov
University of Medicine and Pharmacy “Iuliu Hațieganu”
2023
Highly protein-loaded melt extrudates produced by small-scale ram and twin-screw extrusion - evaluation of extrusion process design on protein stability by experimental and numerical approaches
Katharina Dauer
University of Bonn
2023
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs
Florian Pöstges
University of Bonn
2023
Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution and supersaturation – Influence of processing and hydroxypropyl cellulose grade
Karl Wagner
University of Bonn
2023
Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping
Adrian Krummnow
TU Dortmund University, AbbVie Deutschland
2023
Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism
Stefanie Dohrn
AbbVie Deutschland
2023
Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz
Jacob Rune Jørgensen
University of Copenhagen
2023
Pharmaceutical hot melt extrusion process development using QbD and digital twins
Josip Matić
Research Center Pharmaceutical Engineering GmbH
2023
Simultaneous Water Sorption and Crystallization in ASDs 1: Stability Studies Lasting for Two Years
Gabriele Sadowski
TU Dortmund, Jannsen Pharmaceutica
2023
Viscoelastic Behavior of Supercooled and Glassy ASDs at Humid Conditions Can Be Predicted
Birte Grönniger
TU Dortmund University
2023
Fabrication of Polymeric Microneedles using Novel Vacuum Compression Molding Technique for Transdermal Drug Delivery
Sharvari M. Kshirsagar
Mercer University
2022
Explaining the Release Mechanism of Ritonavir/PVPVA Amorphous Solid Dispersions
Adrian Krummnow
TU Dortmund University, AbbVie Deutschland
2022
Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems
Jingwen Liu
University of Copenhagen
2022
Visualising liquid transport through coated pharmaceutical tablets using Terahertz pulsed imaging
Runqiao Dong
University of Cambridge
2022
Linear and branched polymer prodrugs of the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine as structural materials for long-acting implants
Anika Shakil
University of Liverpool
2022
Boost of solubility and supersaturation of celecoxib via synergistic interactions of methacrylic acid-ethyl acrylate copolymer (1:1) and hydroxypropyl cellulose in ternary amorphous solid dispersions
Florian Pöstges
University of Bonn
2022
Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion
Tobias Gottschalk
TU Dortmund University, INVITE GmbH
2022
3D Printed Mini-Floating-Polypill for Parkinson’s Disease: Combination of Levodopa, Benserazide, and Pramipexole in Various Dosing for Personalized Therapy
Hellen Windolf
Heinrich Heine University
2022
A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications
Christian E. Ziegler
University of Regensburg
2021
Assessment of the amorphous solid dispersion erosion behavior following a novel small-scale predictive approach
Esther S. Bochmann
AbbVie Deutschland
2021
Impact of incorporated drugs on material properties of amorphous solid dispersions
Karsten Flügel
TU Dortmund University, Merck Healthcare KGaA
2021
Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion
Martin Spoerk
Research Center Pharmaceutical Engineering GmbH
2020
Controlled-Release from High-Loaded Reservoir-Type Systems—A Case Study of Ethylene-Vinyl Acetate and Progesterone
Ioannis Koutsamanis
Research Center Pharmaceutical Engineering GmbH, University of Graz
2020
Developing HME-Based Drug Products Using Emerging Science: a Fast-Track Roadmap from Concept to Clinical Batch
Josip Matić
Research Center Pharmaceutical Engineering GmbH
2020
Surface Stabilization and Dissolution Rate Improvement of Amorphous Compacts with Thin Polymer Coatings: Can We Have It All?
Dunja Novakovic
University of Helsinki
2020
Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion
Ioannis Koutsamanis
Research Center Pharmaceutical Engineering GmbH, University of Graz
2020
Impact of structural relaxation on mechanical properties of amorphous polymers
Karsten Flügel
TU Dortmund University, Merck Healthcare KGaA
2020
Viscosity of ASDs at humid conditions
Friederike Wolbert
INVITE GmbH, TU Dortmund University
2020
Drug eluting implants in pharmaceutical development and clinical practice
Ashley R. Johnson
Merck & Co., Inc.
2020
Holistic QbD approach for hot-melt extrusion process design space evaluation: Linking materials science, experimentation and process modeling
Rachel C. Evans
AbbVie Deutschland, University of Bonn
2019
Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
Maximilian Karl
University of Copenhagen, Danish National Research Foundation and Villum Fondens Center
2019
Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings
Ioannis Koutsamanis
Research Center Pharmaceutical Engineering GmbH, University of Graz
2019
Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization
T.R. Hörmann
Graz University of Technology
2018
Establishment of a Molding Procedure to Facilitate Formulation Development for Co-extrudates
Simone Eder
Research Center Pharmaceutical Engineering GmbH
2017
Injection molding as a one-step process for the direct production of pharmaceutical dosage forms from primary powders
K. Eggenreich
Research Center Pharmaceutical Engineering GmbH
2016

Material Characterization

Our customers use flawless VCM samples for various measurement methods such as DSC, hardness, notch impact strength, heat capacity, solubility, DMTA, microscopy, etc. Discover how researchers used VCM Technology for their material characterization research projects.

​Ask for support. Our experts are always happy to discuss and explore new applications.

Title
Authors
Company/Institution
Year
How entanglements determine the morphology of semicrystalline polymers
Zefan Wang
Martin Luther University
2023
Characterization of the temperature and frequency dependency of the complex Poisson’s ratio using a novel combined torsional-axial rheometer
José Alberto Rodríguez Agudo
Anton Paar
2023
Lignin-based benzoxazines: A tunable key-precursor for the design of hydrophobic coatings, fire resistant materials and catalyst-free vitrimers
Antoine Adjaoud
Luxembourg Institute of Science and Technology, University of Luxembourg
2023
The Semicrystalline Morphology of Polybutylene Succinate Supports a General Scheme Based on Intracrystalline Dynamics
Qiang Yu
Martin Luther University
2023
Open-Celled Foams of Polyethersulfone/Poly(N-vinylpyrrolidone) Blends for Ultrafiltration Applications
Aniket Raje
Institute of Membrane Research
2022
Design of Polymeric Zwitterionic Solid Electrolytes with Superionic Lithium Transport
Seamus D. Jones
University of California
2022
How Shape Memory Effects can Contribute to Improved Self-Healing Properties in Polymer Materials
Elizaveta V. Selezneva
A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
2021
Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly Lactic-co-glycolic Acid Microspheres
Talia A. Shmool
University of Cambridge, AstraZeneca
2019
Rheology in shear and elongation and dielectric spectroscopy of polystyrene-block-poly(4-vinylpyridine) diblock copolymers
Tarek Kollmetz
Helmholtz-Zentrum Geesthacht
2017
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