VCM_HME ASD and implant formulation screening

VCM Publications

MeltPrep accelerates research.

Good sample quality is vital for reliable and reproducible material characterizations. Scientific users and quality managers get the most out of their characterization from flawless samples. VCM is a novel approach to screening polymers using a minimum quantity of active pharmaceutical ingredients. Read our latest publication to find out.

Pharmaceutical Applications

VCM Technology is designed for highly challenging pharmaceutical requirements. Our system's benefits have already attracted the attention of different industries. Read the peer-reviewed publications and explore the different pharmaceutical applications involving VCM Technology.

Title	Authors	Company/Institution	Year
Micro-Scale Vacuum Compression Molding as a Predictive Screening Tool of Protein Integrity for Potential Hot-Melt Extrusion Processes	Katharina Dauer	University of Bonn	2023
An isocratic RP-HPLC-UV method for simultaneous quantification of tizanidine and lidocaine: application to in vitro release studies of a subcutaneous implant	Camila J. Picco	Queen's University Belfast	2023
3D Printing of prolonged-release oral solid dosage forms containing felodipine	R. Iuliu Iovanov	University of Medicine and Pharmacy “Iuliu Hațieganu”	2023
Highly protein-loaded melt extrudates produced by small-scale ram and twin-screw extrusion - evaluation of extrusion process design on protein stability by experimental and numerical approaches	Katharina Dauer	University of Bonn	2023
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs	Florian Pöstges	University of Bonn	2023
Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution and supersaturation – Influence of processing and hydroxypropyl cellulose grade	Karl Wagner	University of Bonn	2023
Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping	Adrian Krummnow	TU Dortmund University, AbbVie Deutschland	2023
Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism	Stefanie Dohrn	AbbVie Deutschland	2023
In vitro-in vivo relationship for amorphous solid dispersions using a double membrane dissolution-permeation setup	Jacob Rune Jørgensen	University of Copenhagen, Losan Pharma, SE Tylose, Harke Pharma GmbH, Bioneer:FARMA	2023
Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz	Jacob Rune Jørgensen	University of Copenhagen	2023
Pharmaceutical hot melt extrusion process development using QbD and digital twins	Josip Matić	Research Center Pharmaceutical Engineering GmbH	2023
Simultaneous Water Sorption and Crystallization in ASDs 1: Stability Studies Lasting for Two Years	Gabriele Sadowski	TU Dortmund, Jannsen Pharmaceutica	2023

Material Characterization

Our customers use flawless VCM samples for various measurement methods such as DSC, hardness, notch impact strength, heat capacity, solubility, DMTA, microscopy, etc. Discover how researchers used VCM Technology for their material characterization research projects.

Title	Authors	Company/Institution	Year
Characterization of the temperature and frequency dependency of the complex Poisson’s ratio using a novel combined torsional-axial rheometer	José Alberto Rodríguez Agudo	Anton Paar	2023
Lignin-based benzoxazines: A tunable key-precursor for the design of hydrophobic coatings, fire resistant materials and catalyst-free vitrimers	Antoine Adjaoud	Luxembourg Institute of Science and Technology, University of Luxembourg	2023
The Semicrystalline Morphology of Polybutylene Succinate Supports a General Scheme Based on Intracrystalline Dynamics	Qiang Yu	Martin Luther University	2023
Synthesis and Characterization of Quadrupolar-Hydrogen-Bonded Polymeric Ionic Liquids for Potential Self-Healing Electrolytes	Chenming Li	Martin Luther University	2022
Open-Celled Foams of Polyethersulfone/Poly(N-vinylpyrrolidone) Blends for Ultrafiltration Applications	Aniket Raje	Institute of Membrane Research	2022
Design of Polymeric Zwitterionic Solid Electrolytes with Superionic Lithium Transport	Seamus D. Jones	University of California	2022
Influence of Carbon Dioxide on the Glass Transition of Styrenic and Vinyl Pyridine Polymers: Comparison of Calorimetric, Creep, and Rheological Experiments	Felix Harden	Helmholtz-Zentrum Hereon	2022
How Shape Memory Effects can Contribute to Improved Self-Healing Properties in Polymer Materials	Elizaveta V. Selezneva	A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences	2021
Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly Lactic-co-glycolic Acid Microspheres	Talia A. Shmool	University of Cambridge, AstraZeneca	2019
Rheology in shear and elongation and dielectric spectroscopy of polystyrene-block-poly(4-vinylpyridine) diblock copolymers	Tarek Kollmetz	Helmholtz-Zentrum Geesthacht	2017

VChamber in Action: Scientific Insights

Explore how the VChamber transforms research with its precise vacuum drying capabilities and adaptability across diverse applications. Discover the latest publications highlighting its impact on innovation and learn how it contributes to groundbreaking advancements in science and technology.

Title	Authors	Company/Institution	Year
Insights into the Capacity Fade of High-Voltage Lithium Cathodes in Solid Polymer Electrolyte Cells	Idan Bar-lev	The Hebrew University of Jerusalem	2025
Enhancing Efficiency, Stability, and Cycle Life of Lithium Metal Electrodeposition in Dry Solid-State Polymer Electrolytes	Idan Bar-lev	The Hebrew University of Jerusalem, Boston University, Ariel University	2024
Synthesis of High-Tg Nonisocyanate Polyurethanes via Reactive Extrusion and Their Batch Foaming	Arpan Datta Sarma	Luxembourg Institute of Science and Technology	2024

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